PD0325901 is a small molecule targeting mitogen-activated protein kinase (MAPK/ERK kinase or MEK) with potential antineoplastic activity. PD0325901, a derivative of MEK inhibitor CI-1040, selectively binds to and inhibits MEK, which may result in the inhibition of the phosphorylation and activation of MAPK/ERK and the inhibition of tumor cell proliferation1,2. Along with the ALK5 inhibitor SB431542, PD0325901 has also been shown to increase the efficiency of reprogramming human primary fibroblasts into induced pluripotent stem (iPS) cells3.
Also available as a 10 mM stock solution in DMSO(Cat. No. 04-0006-02)
Stemgent conveniently provides all the components comprising the 5i/L/A media supplement necessary to support naive pluripotent stem cell applications.
5i(inhibitors):
- Stemolecule PD0325901(04-0006),
- Stemolecule Y27632(04-0012),
- Stemolecule WH-4-023(04-0079),
- Stemolecule SB590885(04-0080),
- Stemolecule IM-12(04-0081) or alternatively,Stemolecule CHIR99021(04-0004)
L:Stemfactor LIF, Human Recombinant(03-0016), and
A:Stemfactor Activin A, Human Recombinant(03-0001)